Ing. Eva Gabrielová, Ph.D.

Eva GABRIELOVÁ (PhD)

 

Contact:                                                                                                       

Department of Medical Chemistry

and Biochemistry

Hněvotínská 3                                                                      

775 15 Olomouc

Czech Republic

e-mail: eva.gabriel@email.cz

 

Research Topics:

  • Biological activity of natural substances, plant extracts (in vitro and in vivo); antioxidant and anti-inflammatory activity; perfusion of heart, preconditioning and postconditioning of heart; cardioprotective effect of polyphenols

 

Position:

2010 – present

junior researcher – Department of Medical Chemistry and Biochemistry/ Institute of Molecular and Translational Medicine, Faculty of  Medicine, Palacky University, Olomouc

 

Education and Postgraduate Training:

2006 – 2010

Ph.D. in Department of Medical Chemistry and Biochemistry, Faculty of

Medicine, Palacký University, Olomouc

The topic of thesis: Mechanisms of regulation of mitochondrial protein expression.

2001 – 2006

Chemical Faculty of Brno University of Technology, Czech Republic

Programme: Chemistry and food technology

Department: Food chemistry and biotechnology.

 

Courses:

2011

Course Oxygraph O2k (Oroboros, Austria)

2008

Complete training in real-time PCR at TATAA Biocenter (Tataabiocenter, Prague)

2007

Qualifying examination according to § 17 of the Act No. 246/1992 coll on Prevention of Cruelty to Animals, as amended (VFU, Brno)

2006 – 2007      

Workshops: Basic procedures of microorganisms cultivation, The technology of the biomass isolation, Methods of biomass desintegration (UP, Olomouc)

2006

In vivo fluorescent microscopy of the cells and metazoan organisms (Plzeň)

2006

Course HACCP-BRC Global Food (Konfirm, s.r.o., Brno)

2005

Course ISO 9001 (Konfirm, s.r.o., Brno)

 

Teaching Experiences:

2007 – present

Seminar of Biochemistry (Faculty of Medicine, Palacký University Olomouc)

2006 – 2014

Seminar of Medical Chemistry (Faculty of Medicine, Palacký University Olomouc)

 

Membership:

2006 – present

Czech Chemical Society

2009 – present

Czech Society for Biochemistry and Molecular Biology

 

Bursaries:

July 2013

38th FEBS Congress (Sankt Petersburg, Russia) – refund of congress fee and accommodation

July 2009

9th Young Scientist Forum (Praha) – refund of all expenditure (student fee, accommodation including 34th FEBS Congress)

July 2007           

32nd FEBS Congress (Wien, Austria)refund of student fee and accommodation

 

Grant Projects (current):

2016-2018

Project GACR 16-16667S – Objasnění mechanismu kardioprotektivních účinků polyfenolů

 

Publications:

  • Original papers (8)
  • Review (1)

 

  • 5 most important:

 

  1. Modriansky M and Gabrielova, E: Uncouple my heart: the benefits of inefficiency. Journal of Bioenergetics and Biomembranes, 41:(2), p. 133-136, 2009.
  2. Gabrielova E, Jaburek, M, Gazak, R, Vostalova, J, Jezek, J, Kren, V, and Modriansky, M: Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism. Journal of Bioenergetics and Biomembranes, 42:(6), p. 499-509, 2010.
  3. Kren V, Marhol, P, Purchartova, K, Gabrielova, E, and Modriansky, M: Biotransformation of Silybin and its Congeners. Current Drug Metabolism, 14:(10), p. 1009-1021, 2013.
  4. Skopalik J, Polakova, K, Havrdova, M, Justan, I, Magro, M, Milde, D, Knopfova, L, Smarda, J, Polakova, H, Gabrielova, E, Vianello, F, Michalek, J, and Zboril, R: Mesenchymal stromal cell labeling by new uncoated superparamagnetic maghemite nanoparticles in comparison with commercial Resovist – an initial in vitro study. International Journal of Nanomedicine, 9:(p. 5355-5372, 2014.
  5. Gabrielova E, Zholobenko AV, Bartosikova L, Necas J, Modriansky M: Silymarin Constituent 2,3-Dehydrosilybin Triggers Reserpine-Sensitive Positive Inotropic Effect in Perfused Rat Heart. Plos On, 10: (9), 2015. DOI: 1371/journal.pone.0139208. Article Number: e0139208.

 

Recent Active and Invited Presentations (conferences, meetings):

2014

Eva Gabrielová, A. Zholobenko, L. Bartošíková, J. Nečas, V. Křen a M. Modrianský: 2,3-dehydrosilybin enhances catecholamine effect in myocardial cells. 18th European Bioenergetics Conference. 11. – 18. 7. 2014, Lisabon, Portugal.

2013

Eva Gabrielová, L. Bartošíková, J. Nečas, V. Křen, M. Jabůrek and M. Modrianský: Adrenergic-like effect of 2,3-dehydrosilybin on perfused adult rat heart. 38th FEBS Congress. 6. – 11. 7. 2013, Sankt Petersburg, Russia.

2013

Zholobenko A., Gabrielova E., Necas J., Modriansky M.: Modulation of Adrenergic Signalling by Flavonoids in Cardioprotection. 58th Annual Meeting of the Biophysical-Society. 15. – 19. 2. 2014 San Francisco, CA, USA.

2012

Gabrielová E., Kren V., Jaburek M., Modrianský M.: 2,3-Dehydrosilybin mimics the effect of postconditioning in rat neonatal cardiomyocytes. 17th European Bioenergetics Conference. 15. – 20. 7. 2012, Freiburg, Germany.

2011

Modrianský M., Gažák R., Popelková H., Křen V. and Gabrielová E.: Structural Requirements for Uncoupler-like Activity of 2,3-Dehydrosilybin. Diet and Optimum Health. 13. – 15. 9. 2011, Oregon

 

Recent Awards:

2016

Prize for scientific publication awarded by Dean of Faculty of Medicine, Palacký University Olomouc for Gabrielova E, Zholobenko AV, Bartosikova L, Necas J, Modriansky M: Silymarin Constituent 2,3-Dehydrosilybin Triggers Reserpine-Sensitive Positive Inotropic Effect in Perfused Rat Heart. Plos On, 10: (9), 2015.