Ing. Eva Gabrielová, Ph.D.




Department of Medical Chemistry

and Biochemistry

Hněvotínská 3                                                                      

775 15 Olomouc

Czech Republic



Research Topics:

  • Biological activity of natural substances, plant extracts (in vitro and in vivo); antioxidant and anti-inflammatory activity; perfusion of heart, preconditioning and postconditioning of heart; cardioprotective effect of polyphenols



2010 – present

junior researcher – Department of Medical Chemistry and Biochemistry/ Institute of Molecular and Translational Medicine, Faculty of  Medicine, Palacky University, Olomouc


Education and Postgraduate Training:

2006 – 2010

Ph.D. in Department of Medical Chemistry and Biochemistry, Faculty of

Medicine, Palacký University, Olomouc

The topic of thesis: Mechanisms of regulation of mitochondrial protein expression.

2001 – 2006

Chemical Faculty of Brno University of Technology, Czech Republic

Programme: Chemistry and food technology

Department: Food chemistry and biotechnology.




Course Oxygraph O2k (Oroboros, Austria)


Complete training in real-time PCR at TATAA Biocenter (Tataabiocenter, Prague)


Qualifying examination according to § 17 of the Act No. 246/1992 coll on Prevention of Cruelty to Animals, as amended (VFU, Brno)

2006 – 2007      

Workshops: Basic procedures of microorganisms cultivation, The technology of the biomass isolation, Methods of biomass desintegration (UP, Olomouc)


In vivo fluorescent microscopy of the cells and metazoan organisms (Plzeň)


Course HACCP-BRC Global Food (Konfirm, s.r.o., Brno)


Course ISO 9001 (Konfirm, s.r.o., Brno)


Teaching Experiences:

2007 – present

Seminar of Biochemistry (Faculty of Medicine, Palacký University Olomouc)

2006 – 2014

Seminar of Medical Chemistry (Faculty of Medicine, Palacký University Olomouc)



2006 – present

Czech Chemical Society

2009 – present

Czech Society for Biochemistry and Molecular Biology



July 2013

38th FEBS Congress (Sankt Petersburg, Russia) – refund of congress fee and accommodation

July 2009

9th Young Scientist Forum (Praha) – refund of all expenditure (student fee, accommodation including 34th FEBS Congress)

July 2007           

32nd FEBS Congress (Wien, Austria)refund of student fee and accommodation


Grant Projects (current):


Project GACR 16-16667S – Objasnění mechanismu kardioprotektivních účinků polyfenolů



  • Original papers (8)
  • Review (1)


  • 5 most important:


  1. Modriansky M and Gabrielova, E: Uncouple my heart: the benefits of inefficiency. Journal of Bioenergetics and Biomembranes, 41:(2), p. 133-136, 2009.
  2. Gabrielova E, Jaburek, M, Gazak, R, Vostalova, J, Jezek, J, Kren, V, and Modriansky, M: Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism. Journal of Bioenergetics and Biomembranes, 42:(6), p. 499-509, 2010.
  3. Kren V, Marhol, P, Purchartova, K, Gabrielova, E, and Modriansky, M: Biotransformation of Silybin and its Congeners. Current Drug Metabolism, 14:(10), p. 1009-1021, 2013.
  4. Skopalik J, Polakova, K, Havrdova, M, Justan, I, Magro, M, Milde, D, Knopfova, L, Smarda, J, Polakova, H, Gabrielova, E, Vianello, F, Michalek, J, and Zboril, R: Mesenchymal stromal cell labeling by new uncoated superparamagnetic maghemite nanoparticles in comparison with commercial Resovist – an initial in vitro study. International Journal of Nanomedicine, 9:(p. 5355-5372, 2014.
  5. Gabrielova E, Zholobenko AV, Bartosikova L, Necas J, Modriansky M: Silymarin Constituent 2,3-Dehydrosilybin Triggers Reserpine-Sensitive Positive Inotropic Effect in Perfused Rat Heart. Plos On, 10: (9), 2015. DOI: 1371/journal.pone.0139208. Article Number: e0139208.


Recent Active and Invited Presentations (conferences, meetings):


Eva Gabrielová, A. Zholobenko, L. Bartošíková, J. Nečas, V. Křen a M. Modrianský: 2,3-dehydrosilybin enhances catecholamine effect in myocardial cells. 18th European Bioenergetics Conference. 11. – 18. 7. 2014, Lisabon, Portugal.


Eva Gabrielová, L. Bartošíková, J. Nečas, V. Křen, M. Jabůrek and M. Modrianský: Adrenergic-like effect of 2,3-dehydrosilybin on perfused adult rat heart. 38th FEBS Congress. 6. – 11. 7. 2013, Sankt Petersburg, Russia.


Zholobenko A., Gabrielova E., Necas J., Modriansky M.: Modulation of Adrenergic Signalling by Flavonoids in Cardioprotection. 58th Annual Meeting of the Biophysical-Society. 15. – 19. 2. 2014 San Francisco, CA, USA.


Gabrielová E., Kren V., Jaburek M., Modrianský M.: 2,3-Dehydrosilybin mimics the effect of postconditioning in rat neonatal cardiomyocytes. 17th European Bioenergetics Conference. 15. – 20. 7. 2012, Freiburg, Germany.


Modrianský M., Gažák R., Popelková H., Křen V. and Gabrielová E.: Structural Requirements for Uncoupler-like Activity of 2,3-Dehydrosilybin. Diet and Optimum Health. 13. – 15. 9. 2011, Oregon


Recent Awards:


Prize for scientific publication awarded by Dean of Faculty of Medicine, Palacký University Olomouc for Gabrielova E, Zholobenko AV, Bartosikova L, Necas J, Modriansky M: Silymarin Constituent 2,3-Dehydrosilybin Triggers Reserpine-Sensitive Positive Inotropic Effect in Perfused Rat Heart. Plos On, 10: (9), 2015.