PharmDr. Kateřina Lněničková, Ph.D.

Kateřina Lněničková (MSc., PhD)

Department of Medical Chemistry and Biochemistry

Hněvotínská 3

775 15 Olomouc, Czech Republic

e-mail: katerina.lnenickova@upol.cz

tel: +420 585 63 2346

 

 

Research Topics:

  • Biotransformation enzymes and their modulation by drugs and dietary supplements

 

Position:

2018 – present           

researcher at Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Olomouc

 

Education and postgraduate training:

2013 – 2017

PhD student at Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University

2008 – 2013

Master`s Degree, Faculty of Pharmacy in Hradec Kralove, Charles University

 

Teaching activites:

2014 – 2017

Practical exercises of General Biochemistry (Faculty of Pharmacy in Hradec Kralove, Charles University)

2014 – 2017

Practical exercises of Xenobiochemistry (Faculty of Pharmacy in Hradec Kralove, Charles University)

 

Research Fellowships:

2014

Faculty of Pharmacy, Department of Life Sciences, Pharmacology Section, University of Siena, Italy

 

 Pubications:

 Original papers (7)

 

  • 5 most important:

 

  1. Lnenickova K., Svobodova H., Skalova L., Ambroz M., Novak F., Matouskova P. (2017): The impact of sesquiterpenes beta-caryophyllene oxide and trans-nerolidol on xenobiotic-metabolizing enzymes in mice in vivo. Xenobiotica. 1-9. doi: 10.1080/00498254.2017.1398359.
  2. Lnenickova K., Prochazkova E., Skalova L., Matouskova P., Bartikova H., Soucek P., Szotakova B. (2016): Catechins Variously Affect Activities of Conjugation Enzymes in Proliferating and Differentiated Caco-2 Cells. Molecules. 21. doi: 10.3390/molecules21091186.
  3. Lněničková K., Dymáková A., Szotáková B., Boušová I. (2017): Sulforaphane Alters β-Naphthoflavone-Induced Changes in Activity and Expression of Drug-Metabolizing Enzymes in Rat Hepatocytes. Molecules, 22(11), 1983; doi:10.3390/molecules22111983
  4. Spicakova A., Szotakova B., Dimunova D., Mysliveckova Z., Kubicek V., Ambroz M., Lnenickova K., Krasulova K., Anzenbacher P., Skalova L. (2017): Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions. Molecules. 22. doi: 10.3390/molecules22040509.
  5. Nguyen L. T., Mysliveckova Z., Szotakova B., Spicakova A., Lnenickova K., Ambroz M., Kubicek V., Krasulova K., Anzenbacher P., Skalova L. (2017): The inhibitory effects of beta-caryophyllene, beta-caryophyllene oxide and alpha-humulene on the activities of the main drug-metabolizing enzymes in rat and human liver in vitro. Chem Biol Interact. 278, 123-128. doi: 10.1016/j.cbi.2017.10.021

 

Recent Active and Invited Presentations:

2017

XXIX. Xenobiochemické symposium, 24.-26.5.2017 Telč, Czech Republic

Abstract: Lněničková K., Svobodová H., Skálová L., Ambrož M., Matoušková P., Szotáková B., β-caryophyllene oxide and trans-nerolidol induce cytochrome P450 in mouse small intestine in vivo. Published in Book of Abstracts 2016, 42

2016

Bioactive Natural Products: Translating Promise into Practice, 11.-13.7.2016 St. Catherine College, Oxford, UK

Abstract Lněničková K., Skálová L., Bártíková H., Matoušková P., Szotáková B., Effect of prenylated flavonoids on biotransformation enzymes in Caco-2 cell line. Published in Book of Abstracts 2016, P10

2016

XXV. Biochemický sjezd, 13. – 16. 9. 2016 Praha, Czech Republic

Abstract: Lněničková K., Matoušková P., Skálová L., Szotáková B., Srovnání vlivu β-naftoflavonu na aktivitu, koncentraci proteinů a hladinu mRNA biotransformačních enzymů., Published in Book of Abstracts 2016, 211

2015

XXVIII. Xenobiochemické symposium, 17. – 19.6.2015 Kremnica, Slovak Republic

Abstract: Lněničková K., Szotáková B., Skálová L., Bártíková H., Pakostová A., The activities of conjugation enzymes in proliferating and differentiated Caco-2 cell line. Published in Book of Abstracts 2016, 33

2014

19th North American ISSX Meeting / 29th JSSX Meeting 19.-23.10.2014 San Francisco, Californie, USA

Abstract: Lněničková K., Pokorná P., Szotáková B., In vitro effect of anthocyanins and catechins on activity of selected biotransformation enzymes in intestinal cell lines Published in Book of Abstracts, 2014, 79