Alena Rajnochová Svobodová (Assoc. Prof., PhD, Ing.)
Department of Medical Chemistry and Biochemistry
Hněvotínská 3
775 15 Olomouc, Czech Republic
e-mail: Alf.Svoboda@seznam.cz
tel: +420 585 63 2314
Research Topics:
- plant substances and extracts; biological activity; UVA and UVB toxicity in vitro and in vivo; phototoxic and photoprotective activities; cell lines (HaCaT, Balb/c 3T3, NIH 3T3); primary cell cultures (skin fibroblasts and keratinocytes); human skin explants; SKH-1 hairless mice
Position:
2014 –
Associate Professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Olomouc
Education and postgraduate training:
2009 – 2014
Assistant Profesor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Olomouc
2005 – 2009
researcher, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Olomouc
2002 – 2006
PhD in Biochemistry, Medical Chemistry and Biochemistry, Medical faculty, Palacký University, Olomouc
Thesis: Effect of natural polyphenols on UV irradiation induced damage to keratinocytes
1997– 2002
master Study – Study programme: Chemistry and Technology of Foodstuff
Faculty of Chemistry, Brno University of Technology
Thesis: Utilization of capillary electrophoresis for determination of natural intense sweetener stevioside
Membership:
2006 – present
Czech Chemical Society
2008 – present
European Phytochemical Society
2015 – present
European Society for Photobiology
Teaching activites:
2002 – present
Biochemistry Seminars and Practicals, Czech Programme (Faculty of Medicine, Palacký University Olomouc)
2010 – 2010
Medical Chemistry, Czech Programme (Faculty of Medicine, Palacký University Olomouc)
2009 – present
Biochemistry Seminars and Practicals, English Programme (Faculty of Medicine, Palacký University Olomouc)
2012 – present
Experimental Toxicology, Bioorganic Chemistry (Faculty of Science, Palacký University Olomouc)
2008 – present
Leader of bachelor, diploma and PhD theses
Research Fellowships:
03-05/2005
University of Wolverhampton, Wolverhampton, United Kingdom
Grant Projects (current):
2015 – 2017
GACR 15-10897S – Modulation of human skin cell responses to UVA radiation by silymarin components (member of research team)
Publications:
- 27 original papers
- 3 reviews
- 1 textbooks
- 5 most important:
2016
Rajnochová Svobodová A, Zálešák B, Biedermann D, Ulrichová J, Vostálová J: Phototoxic potential of silymarin and its bioactive components. J Photochem Photobiol B. 2016; 156:61-68.
2013
Rajnochová Svobodová A, Galandáková A, Palíková I, Doležal D, Kylarová D, Ulrichová J, Vostálová J.: Effects of oral administration of Lonicera caerulea berries on UVB-induced damage in SKH-1 mice. A pilot study. Photochem Photobiol Sci. 2013; 12:1830-1840.
2012
Rajnochová Svobodová A, Galandáková A, Šianská J, Doležal D, Lichnovská R, Ulrichová J, Vostálová J.: DNA damage after acute exposure of mice skin to physiological doses of UVB and UVA light. Arch Dermatol Res. 2012; 304:407-412.
2010
Svobodová A, Vostálová J.: Solar radiation induced skin damage: review of protective and preventive options. Int J Radiat Biol 2010; 86:999-1030.
2007
Svobodová A, Zdařilová A, Mališková J, Mikulková H, Walterová D, Vostálová J.: (2007) Attenuation of UVA-induced oxidative damage to human keratinocytes by silymarin. J Derm Sci 2007; 46:21-30.
Recent Active and Invited Presentations (conferences, meetings):
- summary – 64 conference presentations (10 oral)
- last 5 years:
- Rajnochová Svobodová A, Psotová M, Ulrichová J, Zálešák B, Biedermann D, Vostálová J. Phototoxic potential of silymarin and its components. 16th Congress of the European Society for Photobiology. 31.8.-4.9.2015. Aveiro, Portugalsko.
- Cakova V, Vostálová J, Rajnochová Svobodová A, Bonté F, Lobstein A, Ulrichová J. Elastase and collagenase inhibition by Aerides rosea (Orchidaceae) crude extract. 2nd International Conference on Natural Products Utilization: From Plants to Pharmacy Shelf 14.-17.10.2015. Plovdiv, Bulharsko.
- Gerhardová D, Vostálová J, Rajnochová Svobodová A, Ulrichová J, Moravcová M, Muthný T. Comparison of melanoma and keratinocyte cocultures as model for studying pigmentation. XVII. setkání biochemiků a molekulárních biologů. 10.-11.11.2015. Brno, Česká Republika.
- Gerhardová D, Rajnochová Svobodová A, Vostálová J, Ulrichová J, Zálešák B. Modulation of skin cells by UVA radiation. XVII. setkání biochemiků a molekulárních biologů. 11.-12.11.2014. Brno, Česká Republika.
- Teslová P, Rajnochová Svobodová A, Vostálová J, Galandáková A, Kylarová D, Zálešák B, Ullrichová J. Time-stability of human skin explanrs: potential and limitation for research in dermatology. 5th International Conference on Oxidative Stress in Skin Medicine and Biology. 1.-4.9.2011, Andros, Řecko.
Recent Awards:
2006
Dean of Medical Faculty in Olomouc Price for Best PhD Thesis
2007
Dean of Medical Faculty in Olomouc Price for Meaningful scientific publication