Doc. Ing. Alena Rajnochová Svobodová, Ph.D.

Alena Rajnochová Svobodová (ass. prof, PhD)

Department of Medical Chemistry and Biochemistry

Hněvotínská 3

775 15 Olomouc, Czech Republic

e-mail: Alf.Svoboda@seznam.cz

tel: +420 585 63 2314

 

Research Topics:

  • plant substances and extracts; biological activity; UVA and UVB toxicity in vitro and in vivo; phototoxic and photoprotective activities; cell lines (HaCaT, Balb/c 3T3, NIH 3T3); primary cell cultures (skin fibroblasts and keratinocytes); human skin explants; SKH-1 hairless mice

 

Position:

2014 –

Associate Professor, Department of Medical Chemistry and Biochemistry, Faculty of  Medicine, Palacky University, Olomouc

 

Education and postgraduate training:

2009 – 2014

Assistant Profesor, Department of Medical Chemistry and Biochemistry, Faculty of  Medicine, Palacky University, Olomouc

2005 – 2009   

researcher, Department of Medical Chemistry and Biochemistry, Faculty of  Medicine, Palacky University, Olomouc

2002 – 2006

PhD in Biochemistry, Medical Chemistry and Biochemistry, Medical faculty, Palacký University, Olomouc

Thesis: Effect of natural polyphenols on UV irradiation induced damage to keratinocytes

1997– 2002

master Study – Study programme: Chemistry and Technology of Foodstuff

Faculty of Chemistry, Brno University of Technology

Thesis: Utilization of capillary electrophoresis for determination of natural intense sweetener stevioside

 

Membership:

2006 – present

Czech Chemical Society

2008 – present                       

European Phytochemical Society

2015 – present

European Society for Photobiology

 

Teaching activites:

2002 – present

Biochemistry Seminars and Practicals, Czech Programme (Faculty of Medicine, Palacký University Olomouc)

2010 – 2010

Medical Chemistry, Czech Programme (Faculty of Medicine, Palacký University Olomouc)

2009 – present

Biochemistry Seminars and Practicals, English Programme (Faculty of Medicine, Palacký University Olomouc)

2012 – present

Experimental Toxicology, Bioorganic Chemistry (Faculty of Science, Palacký University Olomouc)

2008 – present

Leader of bachelor, diploma and PhD theses

 

Research Fellowships:

03-05/2005

University of Wolverhampton, Wolverhampton, United Kingdom

 

Grant Projects (current):

2015 – 2017               

GACR 15-10897S – Modulation of human skin cell responses to UVA radiation by silymarin components (member of research team)

 

Publications:

  • 27 original papers
  • 3 reviews
  • 1 textbooks

 

  • 5 most important:

2016                          

Rajnochová Svobodová A, Zálešák B, Biedermann D, Ulrichová J, Vostálová J: Phototoxic potential of silymarin and its bioactive components. J Photochem Photobiol B. 2016; 156:61-68.

2013

Rajnochová Svobodová A, Galandáková A, Palíková I, Doležal D, Kylarová D, Ulrichová J, Vostálová J.: Effects of oral administration of Lonicera caerulea berries on UVB-induced damage in SKH-1 mice. A pilot study. Photochem Photobiol Sci. 2013; 12:1830-1840.

2012

Rajnochová Svobodová A, Galandáková A, Šianská J, Doležal D, Lichnovská R, Ulrichová J, Vostálová J.: DNA damage after acute exposure of mice skin to physiological doses of UVB and UVA light. Arch Dermatol Res. 2012; 304:407-412.

2010

Svobodová A, Vostálová J.: Solar radiation induced skin damage: review of protective and preventive options. Int J Radiat Biol 2010; 86:999-1030.

2007

Svobodová A, Zdařilová A, Mališková J, Mikulková H, Walterová D, Vostálová J.: (2007) Attenuation of UVA-induced oxidative damage to human keratinocytes by silymarin. J Derm Sci 2007; 46:21-30.

 

Recent Active and Invited Presentations (conferences, meetings):

  • summary 64 conference presentations (10 oral)

 

  • last 5 years:
  1. Rajnochová Svobodová A, Psotová M, Ulrichová J, Zálešák B, Biedermann D, Vostálová J. Phototoxic potential of silymarin and its components. 16th Congress of the European Society for Photobiology. 31.8.-4.9.2015. Aveiro, Portugalsko.
  2. Cakova V, Vostálová J, Rajnochová Svobodová A,  Bonté F,  Lobstein A, Ulrichová J. Elastase and collagenase inhibition by Aerides rosea (Orchidaceae) crude extract. 2nd International Conference on Natural Products Utilization: From Plants to Pharmacy Shelf 14.-17.10.2015. Plovdiv, Bulharsko.
  3. Gerhardová D, Vostálová J, Rajnochová Svobodová A, Ulrichová J, Moravcová M, Muthný T. Comparison of melanoma and keratinocyte cocultures as model for studying pigmentation. XVII. setkání biochemiků a molekulárních biologů. 10.-11.11.2015. Brno, Česká Republika.
  4. Gerhardová D, Rajnochová Svobodová A, Vostálová J, Ulrichová J, Zálešák B. Modulation of skin cells by UVA radiation. XVII. setkání biochemiků a molekulárních biologů. 11.-12.11.2014. Brno, Česká Republika.
  5. Teslová P, Rajnochová Svobodová A, Vostálová J, Galandáková A, Kylarová D, Zálešák B, Ullrichová J. Time-stability of human skin explanrs: potential and limitation for research in dermatology. 5th International Conference on Oxidative Stress in Skin Medicine and Biology. 1.-4.9.2011, Andros, Řecko.

 

Recent Awards:

2006

Dean of Medical Faculty in Olomouc Price for Best PhD Thesis

2007

Dean of Medical Faculty in Olomouc Price for Meaningful scientific publication