Jiří Vrba (Assoc. Prof., PhD, MSc.)
Department of Medical Chemistry and Biochemistry
Hněvotínská 3
775 15 Olomouc, Czech Republic
e-mail: j.vrba@upol.cz
tel: +420 585 63 2310
Research Topics:
- Molecular toxicology and pharmacology; Biological activity of low molecular weight compounds
- Natural and synthetic compounds; Biological interactions; Biotransformation
Position:
2017
Associate Professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc
Education and employment:
From 2017
Associate Professor, Palacky University, Olomouc
2012 – 2017
Assistant Professor, Palacky University, Olomouc
2004 – 2011
Research Assistant, Palacky University, Olomouc
2001 – 2005
PhD study, Palacky University, Olomouc
1996 – 2001
Analyst, Tekro Ltd, Prague
1990 – 1995
MSc study, Palacky University, Olomouc
Membership:
2002 – present
Czech Chemical Society
2004 – present
Czech Society for Biochemistry and Molecular Biology
Teaching activites:
Biochemistry (Faculty of Medicine and Dentistry, Faculty of Health Sciences, Palacky University, Olomouc)
Research Fellowships:
2005
Sanofi Aventis, Vitry sur Seine, France
2009
University of Texas M. D. Anderson Cancer Center, Houston, USA
Recent publications:
- Vrba J., Havlasek J., Dostalova K., Rysava A., Zapletalova V., Papouskova B., Zalesak B., Storch J., Vacek J. Cannabigerol and cannabidiol differ in their ability to affect the AhR/CYP1A pathway in vitro. Food and Chemical Toxicology 214, art. no. 116156 (2026).
- Zatloukalova M., Fabre G., Jedinak L., Pospíšil J., Dziubak D., Pavićević A., Dostal Z., Vrba J., Sek S., Mojović M., Trouillas P., Vacek J. Lipid membrane behavior of nitro-fatty acids and their loading into liposomes to activate Nrf2 pathway in RAW264.7 cells with impact on intracellular NO production. Chemistry and Physics of Lipids 270, art. no. 105497 (2025).
- Jirasek P., Jusku A., Frankova J., Urbankova M., Diabelko D., Ruzicka F., Papouskova B., Chytilova K., Vrba J., Havlasek J., Langova K., Storch J., Voborna I., Simanek V., Vacek J. Phytocannabinoids and gingival inflammation: Preclinical findings and a placebo-controlled double-blind randomized clinical trial with cannabidiol. Journal of Periodontal Research 59(3), 468-479 (2024).