Jiří Vrba (Assoc. Prof., PhD, MSc.)
Department of Medical Chemistry and Biochemistry
Hněvotínská 3
775 15 Olomouc, Czech Republic
e-mail: j.vrba@upol.cz
tel: +420 585 63 2310
Research Topics:
- Molecular toxicology and pharmacology; Biological activity of low molecular weight compounds
- Natural and synthetic compounds; Biological interactions; Biotransformation
Position:
2017
Associate Professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc
Education and employment:
From 2017
Associate Professor, Palacky University, Olomouc
2012 – 2017
Assistant Professor, Palacky University, Olomouc
2004 – 2011
Research Assistant, Palacky University, Olomouc
2001 – 2005
PhD study, Palacky University, Olomouc
1996 – 2001
Analyst, Tekro Ltd, Prague
1990 – 1995
MSc study, Palacky University, Olomouc
Membership:
2002 – present
Czech Chemical Society
2004 – present
Czech Society for Biochemistry and Molecular Biology
Teaching activites:
2001 – present
Biochemistry (Faculty of Medicine and Dentistry, Palacky University, Olomouc)
2003 – present
Medical chemistry (Faculty of Medicine and Dentistry, Palacky University, Olomouc)
Research Fellowships:
2005
Sanofi Aventis, Vitry sur Seine, France
2009
University of Texas M. D. Anderson Cancer Center, Houston, USA
Publications:
- 38 original papers
- 2 reviews
- 1 textbook
- Recent publications:
Vrba J., Papoušková B., Lněničková K., Kosina P., Křen V., Ulrichová J. Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans. Journal of Pharmaceutical and Biomedical Analysis 178, art. no. 112972 (2020).
Novák D., Vrba J., Zatloukalová M., Roubalová L., Stolarczyk K., Dorčák V., Vacek J. Cysteamine assay for the evaluation of bioactive electrophiles. Free Radical Biology and Medicine 164, 381-389 (2021).
Vrba J., Papoušková B., Lněničková K., Kosina P., Křen V., Ulrichová J. Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases. Antioxidants (Basel) 10(6):954 (2021).
Weber P., Mészáros Z., Jagečić D., Hribljan V., Mitrečić D., Bojarová P., Slámová K., Vrba J., Kulik N., Křen V., Stütz AE. Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer’s disease. Chemical Communications (Camb) 58(63):8838-8841 (2022).