Doc. RNDr. Jitka Vostálová, Ph.D.

Jitka Vostálová (ass. prof, PhD, MSc.)

Department of Medical Chemistry and Biochemistry

Hněvotínská 3

775 15 Olomouc, Czech Republic

e-mail: j.psotova@email.cz

tel: +420 585 63 2316

 

Research Topics:

  • Biological activities of natural substances and their derivatives; Oxidative stress; Total antioxidant status; Enzymatic antioxidants; UVA and UVB toxicity; UVA-Phototoxicity compounds; Photoprotection; Transdermal transport; Anti-ageing activity of natural substances; In vivo experiments (rat and mouse); Clinical trials (Oxidative stress after kidney transplantation; Effect of natural compounds on prostate health; Effect of cranberry on urinary tract infection; Lipidomics of cardiovascular patients).

 

Position:

1995 – 2006

Professor assistant, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc

2006 – present           

Associated professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc

 

Education and postgraduate training:

1992 – 1996

PhD in Biochemistry, Faculty of Science, Masaryk University, Brno

1986 – 1991

Faculty of Science, Masaryk University, Brno; Specialisation: Biochemistry

 

Membership:

2015- present

European Society for Photobiology

 

Teaching activities:

1995 – present

Biochemistry (Faculty of Medicine and Dentistry, Palacký University Olomouc)

1997 – 2004

Medical Chemistry (Faculty of Medicine and Dentistry, Palacký University Olomouc)

1996-2000

Biochemistry; Nursing Pedagogy and Teaching at Secondary Schools for Nurses; a full-time or part-time study programme (Faculty of Education, Palacký University Olomouc)

20002003

Biochemistry; Nursing Pedagogy and Teaching at Secondary Schools for Nurses; part-time study programme (Faculty of Education, Palacký University Olomouc)

2005 – present

Antioxidants and Free Radicals in Health and Diseases (Faculty of Medicine and Dentistry, Palacký University Olomouc)

 

Research Fellowships:

1995

Pharmaceutical Faculty University Paris-Sud, France

2000

School of Pharmacy, Hebrew University, Jerusalem, Izrael

2004

Polytechnic, Pori, Finland

 

Grant Projects:

Detoxification of quaternary isochinoline alkaloids in vitro and in vivo, biological activity their metabolites (527/070871; 2007-2011), MSM 6198959216 – Modulation of signalling and regulatory pathways in normal and cancer cells (2005–2011); Oxidative stress and antioxidant capacity in kidney transplant patients (NS/9964-4; 2009-2011); Development of medical devices based on nanomaterials  (MPO FR-TI2/205; 2010-2013); Lipidomic profiling of patients with cardiovascular diseases (GAČR P206/11/0022; 2011-2013); GAČR 15-10897S – Modulation of human skin cell responses to UVA radiation by silymarin components (2015-2017); IGA_LF_2014_014 – Molecular mechanisms of cytoprotective effects of natural compounds (2014); Innovation of Biochemistry and Clinical Biochemistry of subjects of Faculty Medicine and Dentistry and Faculty of Health Sciences towards better employability of graduates in science , research and practice  (CZ.1.07/2.2.00/15.0293; 2011-2014), Modulation of human skin cell responses to UVA radiation by silymarin components (GACR 15-10897S; 2015 – 2017); IGA_LF_2015_007 – Study of mechanisms of biological activity of natural compounds using cell culture models (2015).

 

Publications:

  • 53 original papers
  • 10 reviews
  • 5 patent
  • 2 textbooks

 

  • 5 most important:

2016

Rajnochová Svobodová A., Zálešák B., Biedermann D., Ulrichová J., Vostálová J. (2016) Phototoxic potential of silymarin and its bioactive components. Journal of Photochemistry and Photobiology B:156, 61-68

2015

Vostalova J., Vidlar A., Simanek V., Galandakova A., Kosina P., Vacek J., Vrbkova J., Zimmermann B.F., Ulrichova J., Student V. Are High Proanthocyanidins Key to Cranberry Efficacy in the Prevention of Recurrent Urinary Tract Infection? Phytotherapy Research. 2015,29, 1559-1567.

2013

Rajnochová Svobodová A, Galandáková A, Palíková I, Doležal D, Kylarová D, Ulrichová J, Vostálová J. (2013) Effects of oral administration of Lonicera caerulea berries on UVB-induced damage in SKH-1 mice. A pilot study. Photochemical and Photobiological Scinces. 12, 1830-1840.

2009

Gažák R., Sedmera P., Vrbacký M., Vostálová J., Drahota Z., Marhol P., Walterová D., Křen V. (2009) Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity-role of individual hydroxyl groups. Free Radic Biology and Medicine 46, 745-758.

2006

Psotová J., Klejdus B., Večeřa R., Kosina P., Kubáň V., Vičar J., Šimánek V., Ulrichová J. (2006) A liquid chromatographic – mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat. Journal of Chromatography B 830, 165-172.

 

Recent Active and Invited Presentations (conferences, meetings):

  • summary – 100

 

  • last 5 years:

2015

Vostálová J., Rajnochová Svobodová A., Ulrichová J., Zálešák B., Biedermann D.

Effects of silymarin and its flavonolignans on UVA-induced damage to normal human fibroblasts. 16th Congress of the European Society for Photobiology, August 31- September 4, 2015, Aveiro, Portugal.

2013

Vostálová J., Kosina P., Novotná L., Zálešák B., Ulrichová J. The effect of UVA radiation on the topical application of benzo[c]phenanthridine alkaloid sanguinarine. 15th Congress European Society for Photobiology. September 2-6, 2013 Liege, Belgium