Prof. Mgr. Martin Modrianský, PhD.

Martin Modrianský (ass. prof, PhD, MSc.)

Department of Medical Chemistry and Biochemistry

Hněvotínská 3

775 15 Olomouc, Czech Republic

e-mail: martin.modriansky@upol.cz

tel: +420 585 63 2319

 

Research Topics:

  • Focus on the biological activities of natural substances, especially polyphenols – influence on the oxidative phosphorylation in mitochondria, influence on cardiac myocytes, influence on microRNA expression.
  • Mitochondria, cardiac myocytes, microRNA, polyphenols

 

Position:

1998 – 2001   

junior researcher, Department of Medical Chemistry and Biochemistry, Faculty of  Medicine, Palacky University, Olomouc

2001 – 2005

Assistant professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Universita Palackého v Olomouci

2005 – 2016

Associate professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Universita Palackého v Olomouci

2016 –

Professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Universita Palackého v Olomouci

 

Education and postgraduate training:

1987 – 1992

Masters program in Biophysics and chemical physics, Faculty of Science, Universita Palackého v Olomouci

1992 – 1997

Ph.D. in Biochemistry, Department of Biochemistry and Molecular Biology, Oregon Graduate Institute, Portland, Ore., U.S.A.

1998 – 2000

Post-doc, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Universita Palackého v Olomouci

 

Membership:

1994 – present

Biophysical Society

1998 – present

Czech Chemical Society

1998 – present                       

Czech Society for Biochemistry and Molecular Biology

 

Teaching activites:

1998 – present

Biochemistry (Faculty of Medicine, Palacký University Olomouc)

2004 – present

Medical chemistry (Faculty of Medicine, Palacký University Olomouc)

 

Research Fellowships:

2000

University of Pittsburgh, Pittsburgh, PA, USA

2001

INSERM U128, Montpellier, France

 

Grant Projects:

2016 – 2018               

GACR – 16-16667S “Deciphering the mechanisms of cardioprotective effects of polyphenols”

 

Publications:

  • 33 original papers
  • 15 reviews
  • 1 textbook
  • 2 chapters in a book

 

  • 7 most important:

Zholobenko A., Modrianský M. (2014) Silymarin and its constituents in cardiac preconditioning. Fitoterapia 97: 122-132. (IF2013 = 2,216)

Modrianský M., Gabrielová E. (2009) Uncouple my heart: the benefits of inefficiency. J Bioenerg Biomembr. 41:133-136. (IF = 4,015)

Vrba J, Dvorák Z, Ulrichová J, Modrianský M. (2008) Conventional protein kinase C isoenzymes undergo dephosphorylation in neutrophil-like HL-60 cells treated by chelerythrine or sanguinarine. Cell Biol Toxicol. 24: 39-53. (IF = 2,155)

Dvořák Z, Modrianský M., Pichard-Garcia L., Balaguer P., Vilarem M.J., Ulrichová J., Maurel P., and Pascussi J.-M. (2003) Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Mol. Pharmacol. 64:160-169. (IF = 5,650)

Arroyo A., Modrianský M., Serinkan F.B., Bello R.I., Matsura T., Jiang J., Tyurin V.A., Tyurina Y.Y., Fadeel B., Kagan V.E. (2002) NADPH oxidase-dependent oxidation and externalization of phosphatidylserine during apoptosis in Me2SO-differentiated HL-60 cells: Role in phagocytic clearance. J. Biol. Chem. 277:49965-49975. (IF = 6,696)

Modrianský M., Patel, H.V., Murdza-Inglis, D. L., Freeman, K. B., and Garlid, K. D. (1997)  Identification by site-directed mutagenesis of three arginines in uncoupling protein that are essential for nucleotide binding and inhibition.  J. Biol. Chem. 272, 24759-24762. (IF = 7,199)

Garlid, K. D., Orosz, D. E., Modrianský, M., Vassanelli, S., and Ježek, P.  (1996)  On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein.  J. Biol. Chem. 271, 2615-2620. (IF = 7,199)