Doc. RNDr. Eva Anzenbacherová, CSc.

Eva Anzenbacherová (Assoc. Prof. RNDr. CSc.)

Doc. RNDr. Eva Anzenbacherová, CSc.

Faculty of  Medicine and Dentistry, Palacky University, Olomouc

Hněvotínská 3

775 15 Olomouc, Czech Republic

eva.anzenbacherova@upol.cz

tel. +420 58 563 2321

 

Research Topics:

Metabolism of xenobiotics; Enzymes of drug biotransformation, Cytochromes P450 and Phase II; enzymes, their structure and function; Bioanalytical methods.

 

Employment:

1984 – 1985

Scientific Assistant, Charles University, Faculty of Sciences, Prague

1985 – 1994

Scientific Assistant, Academy of Sciences of the Czech Republic, Inst. Org. Chem. Biochem., Prague

1994 – 2000

Scientific Assistant, Inst. Experim. Biopharmaceutics, Acad. Sci.- PROMEDcs Joint Institute, Hradec Králové

2001 – 2006

Assistant Professor, Inst. Med. Chem. Biochem., Faculty of Medicine, Palacky University at Olomouc

2006 – recent

Associate Professor (Docent), Inst. Med. Chem. Biochem.,

Faculty of Medicine, Palacky University at Olomouc

 

Education:

1979 –1984

Biochemistry, Faculty of Sciences, Charles University, Prague

1984

Rer. Nat. Dr. (Biochemistry) Faculty of Science, Charles University, Prague

2000

CSc. (Ph.D. equivalent) (Chemistry, Biochemistry), Academy of Sciences of the Czech Republic, Prague

 

Teaching activites:

2001 – present

Biochemistry (Faculty of Medicine, Palacký University Olomouc)

Medical chemistry (Faculty of Medicine, Palacký University Olomouc)

 

Research stays:

1986

Bulgarian Academy of Sciences, Sofia (1 month)

1997, 1998, 2000

INSERM Unité 128, Montpellier, France (short term stays)

2004, 2007, 2010, 2013, 2014

Université de Montpellier 2, INSERM Unité 710, France (short term stays)

 

Publications:

Author and co-author of

  • 74 original papers
  • 6 reviews and
  • 104 contributions at conferences;

 

  1. Anzenbacher P., Anzenbacherová E. Cytochromes P450 and metabolism of xenobiotics. Cell.Mol.Life Sci., 58: 737-747, 2001.
  2. Anzenbacherová E., Bec N., Anzenbacher P., Hudeček J., Souček J., Jung Ch., Munro A.W., Lange R.: Flexibility and stability of the structure of cytochromes P-450 3A4 and  BM-3. Eur.J. Biochem., 267: 2916-2920, 2000.
  3. Veinlichova A, Jancova P, Siller M, Anzenbacher P, Kuca K, Jun D, Fusek J,    Anzenbacherova E. Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro. Chem Biol Interact.180(3):449-53, 2009.
  4. Tomankova V, Liskova B, Skalova L, Bartikova H, Bousova I, Jourova L, Anzenbacher P,   Ulrichova J, Anzenbacherova E.: Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity. Life Sci, 133:15-20, 2015
  5. Matuskova Z, Anzenbacherova E, Vecera R, Tlaskalova-Hogenova H, Kolar M, Anzenbacher P.: Administration of a probiotic can change drug pharmacokinetics: effect  of E. coli Nissle 1917 on amidarone absorption in rats. PLoS One. 2014 Feb 5;9(2):  e87150.  doi: 10.1371/journal.pone.0087150. eCollection 2014.