Osobní profily

Prof. RNDr. Jitka Ulrichová, CSc.

Jitka Ulrichová (Prof., CSc., RNDr.)

Contact:
Department of Medical Chemistry and Biochemistry
Hněvotínská 3, 775 15 Olomouc, Czech Republic
Tel.: +420-585 632 312
Fax.: +420-585 632 302
E-mail: jitka.ulrichova@upol.cz, JitkaUlrichova@seznam.cz

 

Present position and affilation:
Head of the Laboratory of Cell Cultures (from 2002), Medical Faculty, Palacky University, Hněvotínská 3, 775 15 Olomouc
Head of the Department of Medical Chemistry and Biochemistry (from 2008),  Medical Faculty, Palacky University, Hněvotínská 3, 775 15 Olomouc
Vice-rector for Science and Research and Statutary Vice-Rector of the Palacký University Olomouc

 

Major interest:

  • Biological activity of natural substances (cytotoxicity, cytoprotectivity)
  • Mammalian cell cultures (hepatocytes, fibroblasts, keratinocytes).

 

Education:

  • 1972 – 1976
    Secondary School, Olomouc
  • 1976 – 1981
    Biochemistry, Faculty of Science, Masaryk University, Brno
  • 1981 – 1985
  • PhD in Biochemistry, Medical Faculty, Palacký University, Olomouc
  • 1997
    Habilitation, Biochemistry, Pharmaceutical Faculty of Charles University, Hradec Králové
  • 2003
    Professor, Medical Faculty, Palacký University, Olomouc

 

Postdoctoral training:

  • 1990
    Scientific stay, École Nationale Supérieure de Chimie de Paris, France
  • 1992
    FEBS Advanced Course, Louvain-la-Neuve, Belgium
  • 1995
  • Scientific stay, MADAUS AG. Koln, Germany
  • 1996
  • Scientific stay, Institute of Biochemistry, University of Bern, Switzerland
  • 1999, 2000, 2003
    Scientific stay, INSERM, Montpellier, France
  • 2001, 2003
    Scientific stay National Institute of Chemistry, Ljubljana, Slovenia
  • 2001
    School of Medicine, Emory University, Atlanta, U.S.A.

 

Academic appointments:

  • 1985 – 1996
    Professor assistant, Institute of Medical Chemistry, Medical Faculty, Palacký University, Olomouc
  • 1997 – 2003
    Associate professor, Institute of Medical Chemistry, Medical Faculty, Palacký University, Olomouc
  • 2003
    Professor, Institute of Medical Chemistry, Medical Faculty, Palacký University, Olomouc

 

Membership:

  • 1987
    Czech Chemical Society (President since 2006)
  • 1987
    Czech Society for Biochemistry and Molecular Biology
  • 1998
    American Chemical Society
  • 2000
    ESTIV (European Society of Toxicology In Vitro)
  • 2001
    ISSX (International Society for Study of Xenobiotics)
  • 2006
    Phytochemical Society of Europe

 

Publications:

  • 140 original papers,
  • 27 reviews,
  • 5 Czech patents
  • 5 Utility models

 

Citation index (SCI): 1249 (SCOPUS), H-index 20.

 

Recent publications:

  • Vrba J., Vrublova E., Modriansky M., Ulrichova J.: Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. Toxicology Letters 203, 135-141 (2011). |
  • Jurcek O., Ikonen S., Buricova L., Wimmerova M., Wimmer Z., Drasar P., Hornicek J., Galandakova A., Ulrichova J., Kolehmainen E.: Succinobucols New coat – conjugation with steroids to alter its drug effect and bioavailibility. Molecules 16, 9404-9420 (2011).
  • Zatloukalova M., Kren V., Gazak R., Kubala M., Trouillas P., Ulrichova J., Vacek J.: Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II). Bioelectrochemistry 82(2), 117-124 (2011).
  • Gazak R., Valentova K., Fuksova K., Marhol P., Kuzma M., Medina M.A., Oborna I., Ulrichova J., Kren V.: Synthesis and antiangiogenic aktivity of new silybin galloyl esters. J. Med. Chem. 54, 7397-7407 (2011).
  • Vrba J., Trtkova K., Ulrichova J.: HDAC inhibitors sodium butyrate and sodium valproate do not affect human NCOR1 and NCOR2 gene expression in HL-60 cells. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 155, 2593262 (2011).
  • Vrba J., Orolinova E., Ulrichova J.: Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells. Fitoterapia 83, 329-335 (2012).
  • Jakubec P., Bancirova M., Halouzka V., Lojek A., Ciz M., Denev P., Cibicek N., Vacek J., Vostalova J., Ulrichova J., Hrbac J.: Electrochemical sensing and total antioxidant capacity and polyphenol content in winw samples using amperometry online-coupled with microdialysis. J. Agric. Food Chem. 60, 7836-7843 (2012).
  • Noponen V, Belt H, Lahtinen M, Valkonen A, Salo H, Ulrichová J, Galandáková A, Sievänen E.: Bile acid-cysteamine conjugates: Structural properties, gelaton and toxic evaluation. Steroids. 77(3):193-203 (2012).
  • Vacek J, Papoušková B, Kosina P, Vrba J, Křen V, Ulrichová J.: Biotransformation of flavonols and taxifoline in hepatocyte in vitro systems as determined by liquid chromatography with various stationary phases and electrospray ionization-quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 899, 109-15 (2012).