Martin Modrianský (Prof., PhD, MSc.)
Department of Medical Chemistry and Biochemistry
Hněvotínská 3
775 15 Olomouc, Czech Republic
e-mail: martin.modriansky@upol.cz
tel: +420 585 63 2319
Research Topics:
- Focus on the biological activities of natural substances, especially polyphenols – influence on the oxidative phosphorylation in mitochondria, influence on cardiac myocytes, influence on microRNA expression.
- Mitochondria, cardiac myocytes, microRNA, polyphenols
Position:
1998 – 2001
junior researcher, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Olomouc
2001 – 2005
Assistant professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Universita Palackého v Olomouci
2005 – 2016
Associate professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Universita Palackého v Olomouci
2016 –
Professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Universita Palackého v Olomouci
Education and postgraduate training:
1987 – 1992
Masters program in Biophysics and chemical physics, Faculty of Science, Universita Palackého v Olomouci
1992 – 1997
Ph.D. in Biochemistry, Department of Biochemistry and Molecular Biology, Oregon Graduate Institute, Portland, Ore., U.S.A.
1998 – 2000
Post-doc, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Universita Palackého v Olomouci
Membership:
1994 – present
Biophysical Society
1998 – present
Czech Chemical Society
1998 – present
Czech Society for Biochemistry and Molecular Biology
Teaching activites:
1998 – present
Biochemistry (Faculty of Medicine, Palacký University Olomouc)
2004 – present
Medical chemistry (Faculty of Medicine, Palacký University Olomouc)
Research Fellowships:
2000
University of Pittsburgh, Pittsburgh, PA, USA
2001
INSERM U128, Montpellier, France
Grant Projects:
2016 – 2018
GACR – 16-16667S “Deciphering the mechanisms of cardioprotective effects of polyphenols”
Publications:
- 33 original papers
- 15 reviews
- 1 textbook
- 2 chapters in a book
- 7 most important:
Zholobenko A., Modrianský M. (2014) Silymarin and its constituents in cardiac preconditioning. Fitoterapia 97: 122-132. (IF2013 = 2,216)
Modrianský M., Gabrielová E. (2009) Uncouple my heart: the benefits of inefficiency. J Bioenerg Biomembr. 41:133-136. (IF = 4,015)
Vrba J, Dvorák Z, Ulrichová J, Modrianský M. (2008) Conventional protein kinase C isoenzymes undergo dephosphorylation in neutrophil-like HL-60 cells treated by chelerythrine or sanguinarine. Cell Biol Toxicol. 24: 39-53. (IF = 2,155)
Dvořák Z, Modrianský M., Pichard-Garcia L., Balaguer P., Vilarem M.J., Ulrichová J., Maurel P., and Pascussi J.-M. (2003) Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Mol. Pharmacol. 64:160-169. (IF = 5,650)
Arroyo A., Modrianský M., Serinkan F.B., Bello R.I., Matsura T., Jiang J., Tyurin V.A., Tyurina Y.Y., Fadeel B., Kagan V.E. (2002) NADPH oxidase-dependent oxidation and externalization of phosphatidylserine during apoptosis in Me2SO-differentiated HL-60 cells: Role in phagocytic clearance. J. Biol. Chem. 277:49965-49975. (IF = 6,696)
Modrianský M., Patel, H.V., Murdza-Inglis, D. L., Freeman, K. B., and Garlid, K. D. (1997) Identification by site-directed mutagenesis of three arginines in uncoupling protein that are essential for nucleotide binding and inhibition. J. Biol. Chem. 272, 24759-24762. (IF = 7,199)
Garlid, K. D., Orosz, D. E., Modrianský, M., Vassanelli, S., and Ježek, P. (1996) On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein. J. Biol. Chem. 271, 2615-2620. (IF = 7,199)