Lenka Jourová (PhD, MSc.)
Department of Medical Chemistry and Biochemistry
Hněvotínská 3
775 15 Olomouc, Czech Republic
e-mail: lenkajourova@seznam.cz
tel: +420 585 63 2346
Research Topics:
- The role of the human gut microbiome in the metabolism of xenobiotics
- Biotransformation of xenobiotics, cytochromes P450, microbiome
Position:
2012 – present
PhD student at Department of Medical Chemistry and Biochemistry/researcher at Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacky University, Olomouc
Education and postgraduate training:
2012 – present (Ph.D. Study)
Ph.D. Study, Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacky University, Olomouc, Czech Republic
2010 – 2012 (Master Study)
Biochemistry, Faculty of Science, Palacký University, Olomouc, Czech Republic
Diploma thesis: The influence of thyroid hormones on myosine heavy chains expression.
Supervisor: Doc. RNDr. Stanislav Pavelka, Csc.
2007 – 2010 (Bachelor Study)
Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic
Bachelor thesis: Radiometric assays of enzyme activities of iodothyronine deiodinases of type 1 and 3 in fat tissue.
Supervisor: Doc. RNDr. Stanislav Pavelka, Csc.
Research Fellowships:
2014
Institut de Recherche en Biothérapie, Hôpital St. Eloi, Montpellier, France, Université Montpellier I, INSERM U1040 – NORMAL AND MALIGNANT STEM CELLS.
Grant Projects:
2016 – present
IGA_LF_2016_012 Mechanisms of Biological Activity of Natural Substances
2012 – present
GACR P303/12/0535 – Mechanisms of the anti-inflammatory effects of commensal and probiotic bacteria and their role in metabolism and drug pharmacokinetics.
Publications:
- 2015
Tomankova V, Liskova B, Skalova L, Bartikova H, Bousova I, Jourova L, Anzenbacher P, Ulrichova J, Anzenbacherova E: Altered cytochrome P450 activities and expression levels in liver and intestines of monosodium glutamate-induced mouse model of human obesity. Life Sciences, 133, p. 15-20, 2015.
- 2015
Anzenbacherova E., Spicakova A., Jourova L., Ulrichova J., Adamus M., Bachleda P., Anzenbacher P.: Interaction of rocuronium with human liver cytochromes P450. J Pharm Sci, 2015. 127: p. 190-195
Recent Active and Invited Presentations:
2015
51st Congress of the European Societies of Toxicology EUROTOX, Porto, Portugal, 13th-16th September.
Abstract: Lenka Jourová, Pavel Anzenbacher, Zuzana Matušková, Milan Nobilis, Rostislav Večeřa, Helena Tlaskalová-Hogenová, Miloslav Kverka, Milan Kolář and Eva Anzenbacherová. Imipenem, a carbapenem type antibiotic, does not alter pharmacokinetics of a model drug nabumetone.
2014
20th International Symposium on Microsomes and Drug Oxidations, Stuttgart, Germany, 18th – 22nd May
Abstract: Lenka Jourová, Pavel Anzenbacher, Zuzana Matusková, Milan Kolar, Helena Tlaskalová-Hogenová, Miloslav Kverka and Eva Anzenbacherová. Metabolism of nabumetone by commensal and probiotic bacteria under aerobic and anaerobic conditions.
2013
18th Interdisciplinary Czech‐Slovak Toxicology Conference, TOXCON 2013, Hradec Králové, Czech Republic, 19th – 21th June
Abstract: Lenka Jourová, Veronika Tománková, Eva Anzenbacherová, Hana Bártíková, Iva Boušová, Pavel Anzenbacher. Influence of cranberry on activity of cytochromes P450 (CYP) in mouse liver microsomes.