Jitka Vostálová (Assoc. Prof., PhD, MSc.)
Department of Medical Chemistry and Biochemistry
Hněvotínská 3
775 15 Olomouc, Czech Republic
e-mail: j.psotova@email.cz
tel: +420 585 63 2316
Research Topics:
- Biological activities of natural substances and their derivatives; Oxidative stress; Total antioxidant status; Enzymatic antioxidants; UVA and UVB toxicity; UVA-Phototoxicity compounds; Photoprotection; Transdermal transport; Anti-ageing activity of natural substances; In vivo experiments (rat and mouse); Clinical trials (Oxidative stress after kidney transplantation; Effect of natural compounds on prostate health; Effect of cranberry on urinary tract infection; Lipidomics of cardiovascular patients).
Position:
1995 – 2006
Professor assistant, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc
2006 – present
Associated professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc
Education and postgraduate training:
1992 – 1996
PhD in Biochemistry, Faculty of Science, Masaryk University, Brno
1986 – 1991
Faculty of Science, Masaryk University, Brno; Specialisation: Biochemistry
Membership:
2015- present
European Society for Photobiology
Teaching activities:
1995 – present
Biochemistry (Faculty of Medicine and Dentistry, Palacký University Olomouc)
1997 – 2004
Medical Chemistry (Faculty of Medicine and Dentistry, Palacký University Olomouc)
1996-2000
Biochemistry; Nursing Pedagogy and Teaching at Secondary Schools for Nurses; a full-time or part-time study programme (Faculty of Education, Palacký University Olomouc)
2000–2003
Biochemistry; Nursing Pedagogy and Teaching at Secondary Schools for Nurses; part-time study programme (Faculty of Education, Palacký University Olomouc)
2005 – present
Antioxidants and Free Radicals in Health and Diseases (Faculty of Medicine and Dentistry, Palacký University Olomouc)
Research Fellowships:
1995
Pharmaceutical Faculty University Paris-Sud, France
2000
School of Pharmacy, Hebrew University, Jerusalem, Izrael
2004
Polytechnic, Pori, Finland
Grant Projects:
Detoxification of quaternary isochinoline alkaloids in vitro and in vivo, biological activity their metabolites (527/070871; 2007-2011), MSM 6198959216 – Modulation of signalling and regulatory pathways in normal and cancer cells (2005–2011); Oxidative stress and antioxidant capacity in kidney transplant patients (NS/9964-4; 2009-2011); Development of medical devices based on nanomaterials (MPO FR-TI2/205; 2010-2013); Lipidomic profiling of patients with cardiovascular diseases (GAČR P206/11/0022; 2011-2013); GAČR 15-10897S – Modulation of human skin cell responses to UVA radiation by silymarin components (2015-2017); IGA_LF_2014_014 – Molecular mechanisms of cytoprotective effects of natural compounds (2014); Innovation of Biochemistry and Clinical Biochemistry of subjects of Faculty Medicine and Dentistry and Faculty of Health Sciences towards better employability of graduates in science , research and practice (CZ.1.07/2.2.00/15.0293; 2011-2014), Modulation of human skin cell responses to UVA radiation by silymarin components (GACR 15-10897S; 2015 – 2017); IGA_LF_2015_007 – Study of mechanisms of biological activity of natural compounds using cell culture models (2015).
Publications:
- 53 original papers
- 10 reviews
- 5 patent
- 2 textbooks
- 5 most important:
2016
Rajnochová Svobodová A., Zálešák B., Biedermann D., Ulrichová J., Vostálová J. (2016) Phototoxic potential of silymarin and its bioactive components. Journal of Photochemistry and Photobiology B:156, 61-68
2015
Vostalova J., Vidlar A., Simanek V., Galandakova A., Kosina P., Vacek J., Vrbkova J., Zimmermann B.F., Ulrichova J., Student V. Are High Proanthocyanidins Key to Cranberry Efficacy in the Prevention of Recurrent Urinary Tract Infection? Phytotherapy Research. 2015,29, 1559-1567.
2013
Rajnochová Svobodová A, Galandáková A, Palíková I, Doležal D, Kylarová D, Ulrichová J, Vostálová J. (2013) Effects of oral administration of Lonicera caerulea berries on UVB-induced damage in SKH-1 mice. A pilot study. Photochemical and Photobiological Scinces. 12, 1830-1840.
2009
Gažák R., Sedmera P., Vrbacký M., Vostálová J., Drahota Z., Marhol P., Walterová D., Křen V. (2009) Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity-role of individual hydroxyl groups. Free Radic Biology and Medicine 46, 745-758.
2006
Psotová J., Klejdus B., Večeřa R., Kosina P., Kubáň V., Vičar J., Šimánek V., Ulrichová J. (2006) A liquid chromatographic – mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat. Journal of Chromatography B 830, 165-172.
Recent Active and Invited Presentations (conferences, meetings):
- summary – 100
- last 5 years:
2015
Vostálová J., Rajnochová Svobodová A., Ulrichová J., Zálešák B., Biedermann D.
Effects of silymarin and its flavonolignans on UVA-induced damage to normal human fibroblasts. 16th Congress of the European Society for Photobiology, August 31- September 4, 2015, Aveiro, Portugal.
2013
Vostálová J., Kosina P., Novotná L., Zálešák B., Ulrichová J. The effect of UVA radiation on the topical application of benzo[c]phenanthridine alkaloid sanguinarine. 15th Congress European Society for Photobiology. September 2-6, 2013 Liege, Belgium