Pavel Kosina (PhD, MSc.)
Department of Medical Chemistry and Biochemistry
Hněvotínská 3
775 15 Olomouc, Czech Republic
e-mail: pavel.kosina@upol.cz
tel: +420 585 63 2306
Research Topics:
Interaction of natural substances with mammalian cells, Biotransformation, Cell isolation and culture, Bioanalytical methods, HPLC/ HPLC-MS analyses
Position:
2013 – present
Assistant professor, Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Olomouc
2001 – 2013
Researcher, Institute of Medical Chemistry and Biochemistry, Palacký University, Olomouc
1998 – 2000
Researcher, Centre for analytical chemistry of molecular structures, Palacký University, Olomouc
Education and postgraduate training:
2014
Certificate about qualification according to § 17 low ČNR No 246/1992 collection., invested by Central Commission for Animal Protection
1995 – 2000
Ph.D. studies with Ph.D. thesis on “Biological activity of silybin glycosides“, Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Olomouc, Czech Republic
1990 – 1995
MSc. studies in Analytical chemistry with thesis on “Sorption of s‑triazines in soils”, Faculty of Science, Palacký University, Olomouc, Czech Republic
Membership:
1995 – present
Czech Chemical Society
1995 – present
Czech Society for Biochemistry and Molecular Biology
Teaching activites:
2000 – present
Biochemistry (Faculty of Medicine and Dentistry, Palacký University Olomouc)
1995 – 2007
Medical chemistry (Faculty of Medicine and Dentistry, Palacký University Olomouc)
Research Fellowships:
- Study stay (5 months) in Diabetes Research Group, School of Health Sciences, University of Wolverhampton, UK
- Study stay (2 months) in INSERM U128, Montpellier, France
Grant Projects:
2012 – 2018
GACR 303/12/G163 Centre of drug-dietary supplements interactions and nutrigenetics.
2015 – 2017
GA15-10897S Modulation of human skin cell responses to UVA radiation by silymarin components.
2015 – 2018
QJ1510206 Research of the wheat different grain discoloration types caused by substances with antioxidant effects, their use for development of varieties with positive health benefit for human and animal nutrition.
Publications:
- 33 original papers
- 3 textbooks
2016
- HROUZEK P, KAPUSCIK A, VACEK J, VORACOVA K, PAICHLOVA J, KOSINA P, VOLOSHKO L, VENTURA S, KOPECKY J: Cytotoxicity evaluation of large cyanobacterial strain set using selected human and murine in vitro cell models. Ecotoxicology and Environmental Safety 124, 177-185, 2016.
2015
- VOSTALOVA J,VIDLAR A, SIMANEK V, GALANDAKOVA A, KOSINA P, VACEK J, VRBKOVA J, ZIMMERMANN BF, ULRICHOVA J, STUDENT V: Are High Proanthocyanidins Key to Cranberry Efficacy in the Prevention of Recurrent Urinary Tract Infection? Res. 29, 1559-1567 (2015).
2013
- VACEK J, PAPOUŠKOVÁ B, KOSINA P, GALANDÁKOVÁ A, ULRICHOVÁ J: Mass spectrometric investigation of chelerythrine and dihydrochelerythrine biotransformation patterns in human hepatocytes. Chromatogr. B 941, 17-24, 2013.
2011
- KOSINA P, VACEK J, PAPOUŠKOVÁ B, STIBOROVÁ M, STÝSKALA J, CANKAŘ P, VRUBLOVÁ E, VOSTÁLOVÁ J, ŠIMÁNEK V, ULRICHOVÁ J: Identification of benzo[c]phenanthridine metabolites in human hepatocytes by liquid chromatography with electrospray ion-trap and quadrupole time-of-flight mass spektrometry. J. Chromatogr. B 879, 1077-85, 2011.
- KOSINA P, GREGOROVÁ J, GRUZ J, VACEK J, KOLÁŘ M, VOGEL M, ROOS W, NAUMANN ., ŠIMÁNEK V, ULRICHOVÁ J: Phytochemical and antimicrobial characterization of Macleaya cordata herb. Fitoterapia 81, 1006-12,
Recent Active and Invited Presentations (conferences, meetings):
Ulrichová J., Kosina P.: Inovace předmětů biochemie a klinické biochemie v rámci spektra oborů lékařské fakulty a fakulty zdravotnických věd směrem k lepšímu uplatnění absolventů v oblasti vědy, výzkumu i praxe. Biochemický sjezd, Brno, 26.-28.8.2012.
Kosina P., Vacek J., Papoušková B., Šimánek V., Ulrichová J.: Transformation of chelerythrine in human hepatocyte. Biochemický sjezd, Brno, 26.-28.8.2012.
Kosina P., Galandáková A., Snášelová S., Ulrichová J.: In vitro toxicity testing: Influence of different cell lines and endpoints. 18th Congress on Alternatives to Animal Testing, September 16-19, 2013, Linz, Austria, Altex Proceedings 2, 2/13, Linz 2013.