Eva GABRIELOVÁ (PhD, Ing.)
Contact:
Department of Medical Chemistry
and Biochemistry
Hněvotínská 3
775 15 Olomouc
Czech Republic
e-mail: eva.gabriel@email.cz
Research Topics:
- Biological activity of natural substances, plant extracts (in vitro and in vivo); antioxidant and anti-inflammatory activity; perfusion of heart, preconditioning and postconditioning of heart; cardioprotective effect of polyphenols
Position:
2010 – present
junior researcher – Department of Medical Chemistry and Biochemistry/ Institute of Molecular and Translational Medicine, Faculty of Medicine, Palacky University, Olomouc
Education and Postgraduate Training:
2006 – 2010
Ph.D. in Department of Medical Chemistry and Biochemistry, Faculty of
Medicine, Palacký University, Olomouc
The topic of thesis: Mechanisms of regulation of mitochondrial protein expression.
2001 – 2006
Chemical Faculty of Brno University of Technology, Czech Republic
Programme: Chemistry and food technology
Department: Food chemistry and biotechnology.
Courses:
2011
Course Oxygraph O2k (Oroboros, Austria)
2008
Complete training in real-time PCR at TATAA Biocenter (Tataabiocenter, Prague)
2007
Qualifying examination according to § 17 of the Act No. 246/1992 coll on Prevention of Cruelty to Animals, as amended (VFU, Brno)
2006 – 2007
Workshops: Basic procedures of microorganisms cultivation, The technology of the biomass isolation, Methods of biomass desintegration (UP, Olomouc)
2006
In vivo fluorescent microscopy of the cells and metazoan organisms (Plzeň)
2006
Course HACCP-BRC Global Food (Konfirm, s.r.o., Brno)
2005
Course ISO 9001 (Konfirm, s.r.o., Brno)
Teaching Experiences:
2007 – present
Seminar of Biochemistry (Faculty of Medicine, Palacký University Olomouc)
2006 – 2014
Seminar of Medical Chemistry (Faculty of Medicine, Palacký University Olomouc)
Membership:
2006 – present
Czech Chemical Society
2009 – present
Czech Society for Biochemistry and Molecular Biology
Bursaries:
July 2013
38th FEBS Congress (Sankt Petersburg, Russia) – refund of congress fee and accommodation
July 2009
9th Young Scientist Forum (Praha) – refund of all expenditure (student fee, accommodation including 34th FEBS Congress)
July 2007
32nd FEBS Congress (Wien, Austria) – refund of student fee and accommodation
Grant Projects (current):
2016-2018
Project GACR 16-16667S – Objasnění mechanismu kardioprotektivních účinků polyfenolů
Publications:
- Original papers (10)
- Review (1)
- 5 most important:
- Modriansky M and Gabrielova, E: Uncouple my heart: the benefits of inefficiency. Journal of Bioenergetics and Biomembranes, 41:(2), p. 133-136, 2009.
- Gabrielova E, Jaburek, M, Gazak, R, Vostalova, J, Jezek, J, Kren, V, and Modriansky, M: Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism. Journal of Bioenergetics and Biomembranes, 42:(6), p. 499-509, 2010.
- Skopalik J, Polakova, K, Havrdova, M, Justan, I, Magro, M, Milde, D, Knopfova, L, Smarda, J, Polakova, H, Gabrielova, E, Vianello, F, Michalek, J, and Zboril, R: Mesenchymal stromal cell labeling by new uncoated superparamagnetic maghemite nanoparticles in comparison with commercial Resovist – an initial in vitro study. International Journal of Nanomedicine, 9:(p. 5355-5372, 2014.
- Gabrielova E, Zholobenko AV, Bartosikova L, Necas J, Modriansky M: Silymarin Constituent 2,3-Dehydrosilybin Triggers Reserpine-Sensitive Positive Inotropic Effect in Perfused Rat Heart. Plos On, 10: (9), 2015. DOI: 1371/journal.pone.0139208. Article Number: e0139208.
- Gabrielova E, Bartosikova L, Necas J, Modriansky M: Cardioprotective effect of 2,3-dehydrosilybin preconditioning in isolated rat heart. Fitoterapia, 132, p. 12-21, 2019.
Recent Active and Invited Presentations (conferences, meetings):
2018
Gabrielova E, Bartosikova L, Necas J, Modriansky M: Cardioprotective effect of dehydrosilybin preconditioning in isolated rat heart. 20th European Bioenergetics Conference. 25. – 30. 8. 2018, Budapest, Hungary.
Gabrielova E, Bartosikova L, Necas J, Modriansky M: Cardioprotection by 2,3-dehydrosilybin is mediated by signalosomes. 19th International Conference on Oxidative Stress, Redox Homeostasis & Antioxidants: Paris Redox 2017. 25. 6. – 30. 6. 2017, Paris, France.
Gabrielova E, Bartosikova L, Necas J, Modriansky M: Protective role of dehydrosilybin in preconditioned heart. 11th World Congress on Polyphenols Applications.
20. – 21. 6. 2017, Vienna, Austria.
2014
Gabrielova E, A. Zholobenko, L. Bartošíková, J. Nečas, V. Křen a M. Modrianský: 2,3-dehydrosilybin enhances catecholamine effect in myocardial cells. 18th European Bioenergetics Conference. 11. – 18. 7. 2014, Lisabon, Portugal.
2013
Gabrielova E, L. Bartošíková, J. Nečas, V. Křen, M. Jabůrek and M. Modrianský: Adrenergic-like effect of 2,3-dehydrosilybin on perfused adult rat heart. 38th FEBS Congress. 6. – 11. 7. 2013, Sankt Petersburg, Russia.
Recent Awards:
2016
Prize for scientific publication awarded by Dean of Faculty of Medicine, Palacký University Olomouc for Gabrielova E, Zholobenko AV, Bartosikova L, Necas J, Modriansky M: Silymarin Constituent 2,3-Dehydrosilybin Triggers Reserpine-Sensitive Positive Inotropic Effect in Perfused Rat Heart. Plos On, 10: (9), 2015.