Eva Anzenbacherová (Assoc. Prof., CSc., RNDr.)
Faculty of Medicine and Dentistry, Palacky University, Olomouc
Hněvotínská 3
775 15 Olomouc, Czech Republic
tel. +420 58 563 2321
Research Topics:
Metabolism of xenobiotics; Enzymes of drug biotransformation, Cytochromes P450 and Phase II; enzymes, their structure and function; Bioanalytical methods.
Employment:
1984 – 1985
Scientific Assistant, Charles University, Faculty of Sciences, Prague
1985 – 1994
Scientific Assistant, Academy of Sciences of the Czech Republic, Inst. Org. Chem. Biochem., Prague
1994 – 2000
Scientific Assistant, Inst. Experim. Biopharmaceutics, Acad. Sci.- PROMEDcs Joint Institute, Hradec Králové
2001 – 2006
Assistant Professor, Inst. Med. Chem. Biochem., Faculty of Medicine, Palacky University at Olomouc
2006 – recent
Associate Professor (Docent), Inst. Med. Chem. Biochem.,
Faculty of Medicine, Palacky University at Olomouc
Education:
1979 –1984
Biochemistry, Faculty of Sciences, Charles University, Prague
1984
Rer. Nat. Dr. (Biochemistry) Faculty of Science, Charles University, Prague
2000
CSc. (Ph.D. equivalent) (Chemistry, Biochemistry), Academy of Sciences of the Czech Republic, Prague
Teaching activites:
2001 – present
Biochemistry (Faculty of Medicine, Palacký University Olomouc)
Medical chemistry (Faculty of Medicine, Palacký University Olomouc)
Research stays:
1986
Bulgarian Academy of Sciences, Sofia (1 month)
1997, 1998, 2000
INSERM Unité 128, Montpellier, France (short term stays)
2004, 2007, 2010, 2013, 2014
Université de Montpellier 2, INSERM Unité 710, France (short term stays)
Publications:
Author and co-author of
- 74 original papers
- 6 reviews and
- 104 contributions at conferences;
- Anzenbacher P., Anzenbacherová E. Cytochromes P450 and metabolism of xenobiotics. Cell.Mol.Life Sci., 58: 737-747, 2001.
- Anzenbacherová E., Bec N., Anzenbacher P., Hudeček J., Souček J., Jung Ch., Munro A.W., Lange R.: Flexibility and stability of the structure of cytochromes P-450 3A4 and BM-3. Eur.J. Biochem., 267: 2916-2920, 2000.
- Veinlichova A, Jancova P, Siller M, Anzenbacher P, Kuca K, Jun D, Fusek J, Anzenbacherova E. Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro. Chem Biol Interact.180(3):449-53, 2009.
- Tomankova V, Liskova B, Skalova L, Bartikova H, Bousova I, Jourova L, Anzenbacher P, Ulrichova J, Anzenbacherova E.: Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity. Life Sci, 133:15-20, 2015
- Matuskova Z, Anzenbacherova E, Vecera R, Tlaskalova-Hogenova H, Kolar M, Anzenbacher P.: Administration of a probiotic can change drug pharmacokinetics: effect of E. coli Nissle 1917 on amidarone absorption in rats. PLoS One. 2014 Feb 5;9(2): e87150. doi: 10.1371/journal.pone.0087150. eCollection 2014.