RNDr. Marika Svrčková, Ph.D.

Marika Svrčková  (PhD)

Department of Medical Chemistry and Biochemistry

Hněvotínská 3

775 15 Olomouc, Czech Republic

e-mail: svrckova.marika@gmail.com

tel: +420 585 63 2316

 

Maiden name: Janovská (Havlíková)

 

Research Topics:

  • protein glycation analysis, antiglycation activity of natural substances and extracts
  • three-dimensional cell culture

 

Position:

2015 – present          

junior researcher, Department of Medical Chemistry and Biochemistry/ Institute of Molecular and Translational Medicine, Faculty of  Medicine, Palacký University, Olomouc

 

Education and postgraduate training:

2013 – 2015   

post-doctoral position – POST UP project, Faculty of Medicine and Dentistry, Department of Medical Chemistry and Biochemistry, Palacký University, Olomouc, Czech Republic

2010 – 2012

post-doctoral position – GAČR project, Department of Biophyiscs, Faculty of Science, Palacký University, Olomouc, Czech Republic

2006 – 2010

Ph.D., Faculty of Science, Palacký University, Olomouc, Czech Republic
Programme: Biophysics

The topic of thesis: Interaction of small organic molecules with sodium pump

2001 – 2006

MSc., Faculty of Science, Palacký University,  Olomouc, Czech Republic
Programme: Biophysics and Chemical Physics
The topic of thesis: Photosensibilators as a source of reactive oxygen species

 

Teaching activites:

2013 –

Biochemistry (Faculty of Medicine and Dentistry, Palacký University, Olomouc)

2010 – 2012

Experimental methods of biophysics (Faculty of Science, Palacký University, Olomouc)

2006 – 2010

Mechanics, Molecular physics (Faculty of Science, Palacký University, Olomouc)

 

Research Fellowships:

2013

School of Healthcare Science, Laboratory of cell biology and mikrobiology, Manchester Metropolitan University, Manchester, United Kingdom
Research topics: antiglycation activity of natural substances and extracts

2009

Institute of Physiology and Biophysics, Department of Molecular Biology, Aarhus University, Aarhus, Denmark
Research topics: expression and purification of proteins in P. Pastoris, study of small inhibitors of Na,K-ATPase

2007

Institute of Microbiology, Academy of Sciences of the Czech Republic, Laboratory of Secondary Metabolism, Prague, Czech Republic
Research topics: protein expression and purification in E. coli

 

Grant Projects:

2014 – 2016   

New approaches to the study of the intrinsic electroactivity of membrane proteins: focus on structural changes and molecular interactions, GAČR 14-08032S, principal investigator: Jan Vacek

 

Publications:

  • summary: 14
  • 5 most important:

2017

Svrckova M, Zatloukalova M, Dvorakova P, Coufalova D, Novak D, Hernychova L, Vacek J.

Na+/K+-ATPase interaction with methylglyoxal as reactive metabolic side product.

Free Radic Biol Med. 2017 Mar 22;108:146-154.

2015

Havlíková M., Zatloukalová M., Ulrichová J., Dobeš P., and Vacek J: Electrocatalytic Assay for Monitoring Methylglyoxal-Mediated Protein Glycation. Analytical Chemistry 87 (3), 1757-176

2013   

Havlíková M., Huličiak M., Bazgier V., Berka K., Kubala M.: Fluorone dyes have binding sites on both cytoplasmic and extracellular domains of Na,K-ATPase,Biochimica et Biophysica Acta (BBA) – Biomembranes 1828(2), 568-576

2010

Janovská M., Kubala M., Šimánek V., Ulrichová J.: Fluorescence of sanguinarine: spectral changes on interaction with amino acids. Physical Chemistry Chemical Physics 12, 11335-11341

Janovská M., Kubala M., Šimánek V., Ulrichová J.: Interaction of sanguinarine and its dihydroderivative with the Na+/K+-ATPase. Complex view on the old problem. Toxicology Letters 196, 56-59

 

Recent Active and Invited Presentations (poster):

  • summary: 9
  • last 5 years:

2014

FEBS-EMBO Congress 2014, August 30 – September 5, Paris, France

2013

38th FEBS Congress, July 6-11, St. Petersburg, Russia

2012   

37th FEBS and 22nd IUBMB Congress, September 4-9, Sevilla, Spain

Membrane Transport Proteins, GRC Konference, July 1-6, Les Diablerets, Switzerland

2011

13th International ATPase Conference, September 25-October 2, Pacific Grove, CA, USA

4th SFB Symposium 2011, September 8-9, Vienna, Austria

 

Recent Awards:

2010

Dean Award: Author of significant publications in the research field of interest (Faculty of Science)

2016

Dean Award: Author of significant publication in the research field of interest (Faculty of Medicine and Dentistry)